rPeptide 产品列表和技术资料（十一）

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rPeptide是美国一家生物化学研发公司，主要产品涉及领域为老年性痴呆症与帕金森综合症研究使用的重组蛋白，重组多肽，抗体以及试剂等等，另外还提供一系列外包服务，从分子生物学，蛋白表达与蛋白纯化到13C与15N 统一标记蛋白与多肽。同时， rPeptide 技术平台可解决可溶性多肽/蛋白（例如：β-淀粉样蛋白、廋蛋白、前胰岛素）在大肠杆菌中表达等历史性难题。

以下是该公司部分代表产品：

Antibodies（抗体）

Peptides（多肽类）

Proteins（蛋白质）

Neurodegenerative related compounds（神经退行性相关化合物）

Coronavirus research tools（冠状病毒研究工具）

Kits(试剂盒）

Preformed fibrils（预成型的纤维）

rPeptide 产品列表

Preformed Fibrils

货号	名称	规格	产品描述
ASF-1001-05	Alpha-Synuclein Preformed Fibrils	50 μg	These preformed fibrils of α-synuclein may be used as a model for the pathogenic form of α-synuclein in numerous neuropathies. Sourced from E. coli, α-synuclein fibrils were prepared and confirmed by thioflavin assay and electron microscopy. The fibrils can be used for either in vitro requirements such as fibril stability, drug design, aggregation studies, or treatment models. Applications for in vivo experiments include in vivo seeding experiments and preformed fibril injections. The use of these preformed fibrils for in vivo can be advantageous, due to the level of α-synuclein fibrils being more physiological than viral-based or transgenic methods. Alpha-synuclein preformed fibrils may also be used in the study of Parkinson’s Disease or Lewy Body Dementia.
ASF-1001-01	Alpha-Synuclein Preformed Fibrils	100 μg
ASF-1001-1	Alpha-Synuclein Preformed Fibrils	500 μg
ASF-1001-2	Alpha-Synuclein Preformed Fibrils	1.0 mg
AF-1002-1	Beta-Amyloid (1-42) Preformed Fibrils	50 µg	These preformed fibrils of beta-amyloid (1-42) may be used as a model for the pathogenic form of beta-amyloid (1-42) in numerous amyloidosis. Sourced from E. coli, these fibrils were prepared and confirmed by thioflavin assay and electron microscopy. The fibrils can be used for either in vitro experiments such as fibril stability, drug design, aggregation studies, or treatment models. Applications for in vivo experiments include in vivo seeding experiments and preformed fibril injections. Applied to either in vivo or in vitro experiments, these fibrils may be utilized to investigate the mechanism of various amyloid-related neurological disorders.
AF-1002-2	Beta-Amyloid (1-42) Preformed Fibrils	100 µg
AF-1002-3	Beta-Amyloid (1-42) Preformed Fibrils	500 µg
AF-1002-4	Beta-Amyloid (1-42) Preformed Fibrils	1.0 mg
TF-1001-1	Tau-441 Preformed Fibrils	50 µg	These preformed fibrils of tau-441 may be used as a model for the pathogenic form of tau in numerous tauopathies. Sourced from E. coli, tau-441 fibrils were prepared and confirmed by thioflavin assay and electron microscopy, which shows an average size ranging from 50nm-200nm. Applications of this product range from in vitro studies on fibril formation and stability 1 to in vivo studies on cellular uptake, cell viability and pathway activation 2. This product is also suitable for use in mouse models for studies involving memory, neuronal health, or seeding and prion like spreading 3. Recent assessment of the Amyloid hypothesis has led to the realization that wildtype tau is accumulated in various tauopathies including Alzheimer’s disease, Pick’s disease, and progressive supranuclear palsy among others. Applied to either in vivo or in vitro experiments, these fibrils may be utilized to investigate the mechanism of various tauopathies.
TF-1001-2	Tau-441 Preformed Fibrils	100 µg
TF-1001-3	Tau-441 Preformed Fibrils	500 µg