【Merck】肿瘤研究靶点大全

乳腺癌 

Breast Cancer

Gene Name

Gene Symbol

ATP binding cassette subfamily G member 2 (Junior blood group)

ABCG2

BRCA1 associated RING domain 1

BARD1

BRCA1 DNA repair associated

BRCA1

BRCA2 DNA repair associated

BRCA2

BRMS1 transcriptional repressor and anoikis regulator

BRMS1

checkpoint kinase 2

CHEK2

cyclin D1

CCND1

cytochrome P450 family 19 subfamily A member 1

CYP19A1

erb-b2 receptor tyrosine kinase 2

ERBB2

erb-b2 receptor tyrosine kinase 3

ERBB3

estrogen receptor 1

ESR1

estrogen receptor 2

ESR2

kinase catalytic subunit alpha

PIK3CA

mucin 1, cell surface associated

MUC1

nuclear receptor coactivator 3

NCOA3

partner and localizer of BRCA2

PALB2

progesterone receptor

PGR

RAD51 recombinase

RAD51

TOX high mobility group box family member 3

ToX3

tumor protein p53

TP53

直肠癌 

Colon Cancer

Gene Name

Gene Symbol

APC regulator of WNT signaling pathway

APC

B-Raf proto-oncogene, serine/threonine kinase

BRAF

cadherin 1

CDH1

catenin beta 1

CTNNB1

caudal type homeobox 2

CDX2

colon cancer associated transcript 1

CCAT1

colon cancer associated transcript 2

CCAT2

KRAS proto-oncogene，GTPase

KRAS

leucine rich repeat containing G protein-coupled receptor 5

LGR5

MET transcriptional regulator MACC1

MACC1

mucin 2, oligomeric mucus/gel-forming

MUC2

mutL homolog 1

MLH1

mutS homolog 2

MSH2

mutS homolog 6

MSH6

mutY DNA glycosylase

MUTYH

PMS1 homolog 2, mismatch repair system component

PMS2

prominin 1

PROM1

prostaglandin-endoperoxide synthase 2

PTGS2

protein tyrosine phosphatase type IVA, member 3

PTP4A3

tumor protein p53

TP53

食道癌 

Esophageal Cancer

Gene Name

Gene Symbol

alcohol dehydrogenase 1B (class I), beta polypeptide

ADH1B

aldehyde dehydrogenase 2 family member

ALDH2

aurora kinase A

AURKA

cadherin 1

CDH1

cancer/testis antigen 1B

CTAG1B

caudal type homeobox 2

CDX2

cyclin D1

CCND1

cyclin dependent kinase inhibitor 2A

CDKN2A

cytochrome P450 family 1 subfamily A member 1

CYP1A1

DLEC1 cilia and flagella associated protein

DLEC1

epidermal growth factor receptor

EGFR

erb-b2 receptor tyrosine kinase 2

ERBB2

ERCC excision repair 2, TFIIH core complex helicase subunit

ERCC2

phospholipase C epsilon 1

PLCE1

prostaglandin-endoperoxide synthase 2

PTGS2

serine peptidase inhibitor, Kazal type 7 (putative)

SPINK7

solute carrier family 52 member 3

SLC52A3

transmembrane serine protease 11A

TMPRSS11A

tumor protein p53

TP53

vascular endothelial growth factor C

VEGFC

霍奇金淋巴癌 

Hodgkin’s Lymphoma

Gene Name

Gene Symbol

BCL2 apoptosis regulator

BCL2

BCL6 transcription repressor

BCL6

CD274 molecule

CD274

CD68 molecule

CD68

Fc fragment of IgG receptor IIla

FCGR3A

germinal center associated signaling and motility

GCSAM

glutathione S-transferase pi 1

GSTP1

interferon regulatory factor 4

IRF4

interleukin 10

IL10

lymphotoxin alpha

LTA

membrane spanning 4-domains A1

MS4A1

MYC proto-oncogene, bHLH transcription factor

MYC

N-acetyltransferase 1

NAT1

paired box 5

PAX5

PR/SET domain 1

PRDM1

programmed cell death 1

PDCD1

REL proto-oncogene, NF-kB subunit

REL

TNF alpha induced protein 3

TNFAIP3

TNF receptor superfamily member 8

TNFRSF8

TNF superfamily member 8

TNFSF8

肾癌 

Kidney Cancer

Gene Name

Gene Symbol

APC membrane recruitment protein 1

AMER1

apolipoprotein L1

APOL1

BRCA1 associated protein 1

BAP1

carbonic anhydrase 9

CA9

endothelial PAS domain protein 1

EPAS1

folliculin

FLCN

fumarate hydratase

FH

hypoxia inducible factor 1 subunit alpha

HIF1A

mechanistic target of rapamycin kinase

MTOR

paired box 2

PAX2

paired box 8

PAX8

polybromo 1

PBRM1

proline rich mitotic checkpoint control factor

PRCC

SET domain containing 2, histone lysine methyltransferase

SETD2

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1

SMARCB1

transcription factor binding to IGHM enhancer 3

TFE3

TSC complex subunit 2

TSC2

vascular endothelial growth factor A

VEGFA

von Hippel-Lindau tumor suppressor

VHL

Wilms tumor 1

WT1

喉癌 

Laryngeal Cancer

Gene Name

Gene Symbol

alcohol dehydrogenase 1B (class I), beta polypeptide

ADH1B

alcohol dehydrogenase 1C (class I), gamma polypeptide

ADH1C

baculoviral IAP repeat containing 5

BIRC5

cadherin 1

CDH1

CD44 molecule (Indian blood group

CD44

cyclin D1

CCND1

cyclin dependent kinase inhibitor 2A

CDKN2A

cytochrome P450 family 1 subfamily A member 1

CYP1A1

epidermal growth factor receptor

EGFR

glutathione S-transferase mu 1

GSTM1

glutathione S-transferase mu 3

GSTM3

glutathione S-transferase theta 1

GSTT1

matrix metallopeptidase 9

MMP9

MYC target 1

MYCT1

phosphatase and tensin homolog

PTEN

programmed cell death 4

PDCD4

prostaglandin-endoperoxide synthase 2

PTGS2

tumor protein p53

TP53

X-ray repair cross complementing 3

XRCC3

zinc finger protein X-linked

ZFX

白血病

Leukemia

Gene Name

Gene Symbol

BCR activator of RhoGEF and GTPase

BCR

CCAAT enhancer binding protein alpha

CEBPA

ETS variant 6

ETV6

fms related tyrosine kinase 3

FLT3

IKAROS family zinc finger 1

IKZF1

Janus kinase 2

JAK2

LIF interleukin 6 family cytokine

LIF

LIF receptor alpha

LIFR

lysine methyltransferase 2A

KMT2A

MCL1 apoptosis regulator, BCL2 family member

MCL1

nucleophosmin 1

NPM1

PBX homeobox 1

PBX1

promyelocytic leukemia

PML

receptor tyrosine kinase

ABL1

runt related transcription factor 1

RUNX1

RUNX1 translocation partner 1

RUNX1T1

TAL bHLH transcription factor 1, erythroid differentiation factor

TAL1

tet methylcytosine dioxygenase 2

TET2

WT1 transcription factor

WT1

zinc finger and BTB domain containing 16

ZBTB16

肝癌

Liver Cancer

Gene Name

Gene Symbol

alpha-fetoprotein

AFP

cadherin 17

CDH17

catenin beta 1

CTNNB1

DLC1 Rho GTPase activating protein

DLC1

glypican 3

GPC3

golgi membrane protein 1

GOLM1

hepatocellular carcinoma up-regulated long non-coding RNA

HULC

hepatocyte nuclear factor 4 alpha

HNF4A

MET proto-oncogene, receptor tyrosine kinase

MET

nuclear receptor subfamily 5 group A member 2

NR5A2

patatin like phospholipase domain containing 3

PNPLA3

prominin 1

PROM1

protein tyrosine phosphatase type IVA, member 3

PTP4A3

secreted phosphoprotein 1

SPP1

serine/threonine kinase 11

STK11

signal transducer and activator of transcription 3

STAT3

solute carrier organic anion transporter family member 1B1

SLCO1B1

solute carrier organic anion transporter family member 1B3

SLCO1B3

StAR related lipid transfer domain containing 13

STARD13

Yes associated protein 1

YAP1

黑色素瘤

Melanoma

Gene Name

Gene Symbol

absent in melanoma 2

AIM2

B-Raf proto-oncogene, serine/threonine kinase

BRAF

BRCA1 associated protein 1

BAP1

cancer/testis antigen 1B

CTAG1B

cyclin dependent kinase inhibitor 2A

CDKN2A

glycoprotein nmb

GPNMB

interferon induced with helicase C domain 1

IFIH1

interleukin 24

IL24

KIT proto-oncogene, receptor tyrosine kinase

KIT

MAGE family member A1

MAGEA1

MAGE family member A3

MAGEA3

melan-A

MLANA

melanocortin 1 receptor

MC1R

melanocyte inducing transcription factor

MITF

melanoma cell adhesion molecule

MCAM

MIA SH3 domain containing

MIA

NRAS proto-oncogene, GTPase

NRAS

preferentially expressed antigen in melanoma

PRAME

premelanosome protein

PMEL

tyrosinase

TYR

肺癌

Lung Cancer

Gene Name

Gene Symbol

ALK receptor tyrosine kinase

ALK

CD274 molecule

CD274

cell adhesion molecule 1

CADM1

cholinergic receptor nicotinic alpha 3 subunit

CHRNA3

cholinergic receptor nicotinic alpha 5 subunit

CHRNA5

CLPTM1 like

CLPTM1L

EMAP like 4

EML4

epidermal growth factor receptor

EGFR

ERCC excision repair 1, endonuclease non-catalytic subunit

ERCC1

ERCC excision repair 2, TFIIH core complex helicase subunit

ERCC2

KRAS proto-oncogene,GTPase

KRAS

MET proto-oncogene, receptor tyrosine kinase

MET

metastasis associated lung adenocarcinoma transcript 1

MALAT1

napsin A aspartic peptidase

NAPSA

NK2 homeobox 1

NKX2

Ras association domain family member 1

RASSF1

ROS proto-oncogene 1, receptor tyrosine kinase

ROS1

serine/threonine kinase 11

STK11

tumor protein p53

TP53

X-ray repair cross complementing 1

XRCC1

骨髓瘤

Myeloma

Gene Name

Gene Symbol

BCL2 like 11

BCL2L11

cereblon

CRBN

cyclin D1

CCND1

dickkopf WNT signaling pathway inhibitor 1

DKK1

fibroblast growth factor receptor 3

FGFR3

heparanase

HPSE

interferon regulatory factor 4

IRF4

interleukin 6

IL6

MAF bZip transcription factor

MAF

MAGE family member C1

MAGEC1

MCL1 apoptosis regulator, BCL2 family member

MCL1

MYC proto-oncogene, bHLH transcription factor

MYC

nuclear receptor binding SET domain protein 2

NSD2

PR/SET domain 1

PRDM1

syndecan 1

SDC1

TNF receptor superfamily member 13B

TNFRSF13B

TNF receptor superfamily member 17

TNFRSF17

TNF superfamily member 11

TNFSF11

TNF superfamily member 13b

TNFSF13B

X-box binding protein 1

XBP1

神经系统癌

Nervous System Cancer

Gene Name

Gene Symbol

quaporin 4

AQP4

aryl hydrocarbon receptor interacting protein

AIP

B-Raf proto-oncogene, serine/threonine kinase

BRAF

epidermal growth factor receptor

EGFR

isocitrate dehydrogenase (NADP(+)) 1, cytosolic

IDH1

isocitrate dehydrogenase (NADP(+)) 2, mitochondrial

IDH2

KRIT1 ankyrin repeat containing

KRIT1

marker of proliferation Ki-67

MKI67

MYCN proto-oncogene, bHLH transcription factor

MYCN

nestin

NES

neurofibromin 1

NF1

neurofibromin 2

NF2

O-6-methylguanine-DNA methyltransferase

MGMT

oligodendrocyte transcription factor 2

OLIG2

phosphatase and tensin homolog

PTEN

prominin 1

PROM1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1

SMARCB1

telomerase reverse transcriptase

TERT

tumor protein p53

TP53

von Hippel-Lindau tumor suppressor

VHL

非霍奇金淋巴癌

Non-Hodgkin’s Lymphoma

Gene Name

Gene Symbol

activation induced cytidine deaminase

AICDA

ALK receptor tyrosine kinase

ALK

BCL10 immune signaling adaptor

BCL10

BCL2 apoptosis regulator

BCL2

BCL6 transcription repressor

BCL6

SRY-Box 11

soX11

caspase recruitment domain family member 11

CARD11

cyclin D1

CCND1

Fc fragment of IgG receptor IIla

FCGR3A

forkhead box P1

FOXP1

germinal center associated signaling and motility

GCSAM

immunoglobulin heavy locus

IGH

interferon regulatory factor 4

IRF4

MALT1 paracaspase

MALT1

membrane spanning 4-domains A1

MS4A1

MYC proto-oncogene, bHLH transcription factor

MYC

MYD88 innate immune signal transduction adaptor

MYD88

paired box 5

PAX5

PR/SET domain 1

PRDM1

TNF receptor superfamily member 8

TNFRSF8

口腔癌

Oral Cavity Cancer

Gene Name

Gene Symbol

alcohol dehydrogenase 1C (cass I), gamma polypeptide

ADH1C

cadherin 1

CDH1

CREB regulated transcription coactivator 1

CRTC1

cyclin D1

CCND1

cyclin dependent kinase inhibitor 2A

CDKN2A

cytochrome 450 family 1 subfamily A member 1

CYP1A1

epidermal growth factor receptor

EGFR

glutathione S-transferase mu 1

GSTM1

glutathione S-transferase theta 1

GSTT1

high mobility group AT-hook 2

HMGA2

keratin 13

KRT13

LTO1 maturation factor of ABCE1

LTo1

mastermind like transcriptional coactivator 2

MAML2

matrix metallopeptidase 2

MMP2

PLAG1 zinc finger

PLAG1

podoplanin

PDPN

prostaglandin-endoperoxide synthase 2

PTGS2

tumor protein p53

TP53

tumor protein p63

TP63

vascular endothelial growth factor C

VEGFC

胰腺癌

Pancreatic Cancer

Gene Name

Gene Symbol

angiogenin

ANG

BRCA2 DNA repair associated

BRCA2

cholecystokinin B receptor

CCKBR

cyclin dependent kinase inhibitor 2A

CDKN2A

GLI family zinc finger 1

GLI1

KRAS proto-oncogene, GTPase

KRAS

menin 1

MEN1

mesothelin

MSLN

mucin 1, cell surface associated

MUC1

mucin 4 cell surface associated

MUC4

pancreatic and duodenal homeobox 1

PDX1

partner and localizer of BRCA2

PALB2

S100 calcium binding protein P

S100P

serine peptidase inhibitor, Kazal type 1

SPINK1

serine protease 1

PRSS1

SMAD family member 4

SMAD4

solute carrier family 29 member 1 (Augustine blood group)

SLC29A1

somatostatin receptor 2

SSTR2

sonic hedgehog signaling molecule

SHH

zymogen granule protein 16B

ZG16B

鼻咽癌

Pharyngeal Cancer

Gene Name

Gene Symbol

BPI fold containing family A member 1

BPIFA1

cadherin 1

CDH1

CD44 molecule (Indian blood group)

CD44

cyclin D1

CCND1

cyclin dependent kinase inhibitor 2A

CDKN2A

cytochrome P450 family 2 subfamily E member 1

CYP2E1

enhancer of zeste 2 polycomb repressive complex 2 subunit

EZH2

ERCC excision repair 1, endonuclease non-catalytic subunit

ERCC1

glutathione S-transferase mu 1

GSTM1

major histocompatibility complex, class I, A

HLA

matrix metallopeptidase 9

MMP9

metastasis associated 1

MTA1

organic solute carrier partner 1

OSCP1

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

PIK3CA

Ras association domain family member 1

RASSF1

transmembrane protein 8B

TMEM8B

tumor protein p53

TP53

X-ray repair cross complementing 1

XRCC1

X-ray repair cross complementing 3

XRCC3

zinc finger MYND-type containing 10

ZMYND10

前列腺癌

Prostate Cancer

Gene Name

Gene Symbol

acid phosphatase,prostate

ACPP

alpha-methylacyl-CoA racemase

AMACR

androgen receptor

AR

cytochrome P450 family 17 subfamily A member 1

CYP17A1

elaC ribonuclease Z 2

ELAC2

ETS transcription factor ERG

ERG

folate hydrolase 1

FOLH1

homeobox B13

HOXB13

kallikrein related peptidase 2

KLK2

kallikrein related peptidase 3

KLK3

microseminoprotein beta

MSMB

NK3 homeobox 1

NKX3

phosphatase and tensin homolog

PTEN

pro-apoptotic WT1 regulator

PAWR

prostate cancer associated 3

PCA3

prostate stem cell antigen

PSCA

ribonuclease L

RNASEL

SAM pointed domain containing ETS transcription factor

SPDEF

steroid 5 alpha-reductase 2

SRD5A2

transmembrane serine protease 2

TMPRSS2

结肠癌

Rectal Cancer

Gene Name

Gene Symbol

APC regulator of WNT signaling pathway

APC

B-Raf proto-oncogene, serine/threonine kinase

BRAF

carcinoembryonic antigen related cell adhesion molecule 5

CEACAM5

caspase 3

CASP3

cyclin dependent kinase inhibitor 2A

CDKN2A

dihydropyrimidine dehydrogenase

DPYD

kallikrein related peptidase 3

KLK3

KRAS proto-oncogene，GTPase

KRAS

methylenetetrahydrofolate reductase

MTHFR

mutL homolog 1

MLH1

mutS homolog 2

MSH2

mutY DNA glycosylase

MUTYH

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

PIK3CA

prostate cancer associated 3

PCA3

SMAD family member 3

SMAD3

thymidine phosphorylase

TYMP

thymidylate synthetase

TYMS

tumor protein p53

TP53

X-ray repair cross complementing 1

XRCC1

肾盂癌

Renal Pelvis Cancer

Gene Name

Gene Symbol

aldehyde dehydrogenase 1 family member A1

ALDH1A1

BCL2 associated X, apoptosis regulator

BAX

caspase 3

CASP3

erb-b2 receptor tyrosine kinase 2

ERBB2

hypoxia inducible factor 1 subunit alpha

HIF1A

leptin receptor

LEPR

mutS homolog 2

MSH2

plasminogen activator, urokinase receptor

PLAUR

platelet derived growth factor receptor beta

PDGFRB

PMS1 homolog 2

PMS2

prolyl endopeptidase

PREP

prostaglandin-endoperoxide synthase 2

PTGS2

prothymosin alpha

PTMA

serine/threonine kinase 11

STK11

solute carrier family 2 member 5

SLC2A5

splicing factor proline and glutamine rich

SFPQ

succinate dehydrogenase complex iron sulfur subunit B

SDHB

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4

SMARCA4

telomerase reverse transcriptase

TERT

transcription factor binding to IGHM enhancer 3

TFE3

胃癌 

Stomach Cancer

Gene Name

Gene Symbol

cadherin 1

CDH1

cadherin 17

CDH17

caudal type homeobox 2

CDX2

erb-b2 receptor tyrosine kinase 2

ERBB2

gastrin

GAST

gastrokine 1

GKN1

gastrokine 2

GKN2

interleukin 1 beta

IL1B

interleukin 1 receptor antagonist

ILIRN

MET proto-oncogene, receptor tyrosine kinase

MET

mutL homolog 1

MLH1

pepsinogen 3,group I (pepsinogen A)

PGA3

pepsinogen 4, group I (pepsinogen A)

PGA4

pepsinogen 5,group I (pepsinogen A)

PGA5

progastricsin

PGC

prostaglandin-endoperoxide synthase 2

PTGS2

prostate stem cell antigen

PSCA

runt related transcription factor 3

RUNX3

thymidylate synthetase

TYMS

trefoil factor 1

TFF1

睾丸癌 Testicular Cancer

Gene Name

Gene Symbol

binding factor like

CTCFL

cancer/testis antigen 1A

CTAG1A

cancer/testis antigen 1B

CTAG1B

cancer/testis antigen 2

CTAG2

dicer 1, ribonuclease III

DICER1

MAGE family member A1

MAGEA1

MAGE family member A11

MAGEA11

MAGE family member A3

MAGEA3

MAGE family member A4

MAGEA4

MAGE family member C1

MAGEC1

MAGE family member C2

MAGEC2

PAS domain containing repressor 1

PASD1

preferentially expressed antigen in melanoma

PRAME

serine protease 50

PRSS50

sperm autoantigenic protein 17

SPA17

SsX family member 2

ssX2

SSX family member 5

SSX5

testis specific protein Y-linked 1

TSPY1

X antigen family member 1A

XAGE1A

X antigen family member 1B

XAGE1B

甲状腺癌 Thyroid Cancer

Gene Name

Gene Symbol

B-Raf proto-oncogene, serine/threonine kinase

BRAF

forkhead box E1

FOXE1

galectin 3

LGALS3

napsin A aspartic peptidase

NAPSA

NK2 homeobox 1

NKX2

NRAS proto-oncogene, GTPase

NRAS

nuclear receptor corepressor 2

NCOR2

nuclear receptor subfamily 2 group C member 2

NR2C2

nuclear receptor subfamily 4 group A member 3

NR4A3

paired box 8

PAX8

phosphatase and tensin homolog

PTEN

pyruvate kinase M1/2

PKM

ret proto-oncogene

RET

solute carrier family 5 member 5

SLC5A5

telomerase reverse transcriptase

TERT

thyroglobulin

TG

thyroid hormone receptor alpha

THRA

thyroid hormone receptor beta

THRB

thyroid peroxidase

TPO

thyroid stimulating hormone receptor

TSHR

膀胱癌 Urinary Bladder Cancer

Gene Name

Gene Symbol

cadherin

CDH1

ERCC excision repair 2, TFIIH core complex helicase subunit

ERCC2

fibroblast growth factor receptor 3

FGFR3

GATA binding protein 3

GATA3

glutathione S-transferase mu 1

GSTM1

glutathione S-transferase pi 1

GSTP1

glutathione S-transferase theta 1

GSTT1

HRas proto-oncogene,GTPase

HRAS

N-acetyltransferase 1

NAT1

N-acetyltransferase 2

NAT2

NAD(P)H quinone dehydrogenase 1

NQO1

prostate stem cell antigen

PSCA

telomerase reverse transcriptase

TERT

tumor protein p53

TP53

tumor protein p63

TP63

uroplakin 2

UPK2

urothelial cancer associated 1

UCA1

XPC complex subunit, DNA damage recognition and repair factor

XPC

X-ray repair cross complementing 1

XRCC1

X-ray repair cross complementing 3

XRCC3

子宫癌 Uterine Cancer

Gene Name

Gene Symbol

AT-rich interaction domain 1A

ARID1A

cyclin dependent kinase inhibitor 2A

CDKN2A

cytochrome P450 family 19 subfamily A member 1

CYP19A1

estrogen receptor 1

ESR1

estrogen receptor binding site associated antigen 9

EBAG9

fumarate hydratase

FH

high mobility group AT-hook 2

HMGA2

marker of proliferation Ki-67

MKI67

mediator complex subunit 12

MED12

mucin 16, cell surface associated

MUC16

mutL homolog 1

MLH1

mutS homolog 2

MSH2

mutS homolog 6 [Homo sapiens, Entrez-Gene

MSH6

NLR family pyrin domain containing 7

NLRP7

phosphatase and tensin homolog

PTEN

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

PIK3CA

progesterone receptor

PGR

prostaglandin-endoperoxide synthase 2

PTGS2

tumor protein p53

TP53

WAP four-disulfide core domain 2

WFDC2