【Merck】神经退行性疾病、神经细胞等神经科学热门抗体推荐
神经系统疾病研究与治疗挑战源于中枢神经系统（CNS）的结构功能的复杂与不断的动态变化的特性，基于神经及脑科学研究一直以来是科研热点。而抗体在神经研究过程中至关重要，覆盖到IHC, ICC, IF, Western blot，Elisa，Flow cytometry 等多种实验。
默克旗下Chemicon® 品牌，被誉为神经科学研究的“金标准”，提供全面的神经标志物和神经功能研究抗体。
• 高引用率：70,000+篇文献，引用率遥遥领先
• 靶点全覆盖：10,000+种神经抗体
• 多应用验证：IF、IHC/ICC、WB、IP、FACS、ELISA等
神经退行性疾病
神经退行性疾病是进行性神经系统功能障碍，其特点是神经元细胞功能丧失，使人衰弱并且难以治愈。常常与神经系统结构受到影响萎缩有关。神经科学蛋白生物标志物逐渐成为判定疾病如神经系统疾病的重要指标，下面是常见的神经退行性疾病的标志物及相应推荐抗体。
阿尔兹海默症
阿尔茨海默病(AD)是在老年人群中，最常见的痴呆症类型的疾病，其显著特征是认知功能逐渐的丧失。阿尔茨海默病(AD)的典型病理组织学表现包括广泛的神经元变性、细胞外淀粉样斑块和细胞内神经纤维缠结(NFT)。
靶点 | 名称 | 货号 | Species | Application |
APP | Anti-APP A4 Antibody | MAB348 | rat fish human mouse canine pig monkey | IF;IHC;WB |
Tau total | Anti-Tau Antibody | MAB361 | mouse human rat bovine | IHC;WB |
pTau （Thr181） | Anti-phospho-Tau (pThr181) antibody | SAB4504560 | rat human mouse | ELISA;WB |
pTau （Ser396） | Anti-phospho-Tau (pSer396) antibody | SAB4504557 | rat human mouse | ELISA;WB |
Tau-1 | Anti-Tau-1 Antibody | MAB3420 | human rat bovine | IHC;WB |
alpha-synuclein | Anti-Synuclein α Antibody | AB5038 | rat human | ICC;IHC;WB |
NFL | Anti-Neurofilament L Antibody | AB9568 | rat pig human bovine feline canine mouse | ICC;IHC;WB |
BDNF | Anti-BDNF antibody | SAB2108004 | horse rat rabbit dog mouse human pig | WB;IHC |
GSK-3b | Anti-GSK-3b Antibody | 07-1413 | mouse bovine rat human | IHC;IP;WB |
BACE1 | Anti-BACE1 antibody | SAB2100200 | rabbit bovine guinea pig mouse rat horse dog human | IF;IHC;WB |
PSEN2 | Anti-PSEN2 antibody | AV44289 | bovine horse human dog rat guinea pig rabbit mouse | IHC;WB |
PSEN1 | Anti-PSEN1 antibody | HPA030760 | human | IHC |
APOE | Anti-Apolipoprotein E antibody | HPA065539 | human | WB, IHC, ICC |
帕金森疾病
(PD)是一种进展缓慢的运动系统神经退行性病变，其特点是运动功能减退、僵硬和静止性震颤。病理学上帕金森病(PD)的特征是黑质多巴胺能神经元大量变性丢失，导致基底神经节多巴胺递质供应减少。
靶点 | 名称 | 货号 | Species | Application |
PINK1 | Anti-PINK1 antibody | P0076 | mouse (predicted) human rat (predicted) | western blot |
TH | Anti-Tyrosine Hydroxylase Antibody | AB152 | human mollusk feline ferret Aplysia (marine mollusc) rat squid Drosophila mouse | ELISA;IF;IHC;IHC(P);IP;WB |
Parkin | Anti-Parkin antibody | P6248 | mouse rat hamster human | ARR;WB |
SNCA | Anti-SNCA antibody | HPA005459 | human | IHC, WB |
Alpha-synuclein | Anti-Synuclein α Antibody | AB5038 | rat human | ICC;IHC;WB |
Alpha-synuclein (phospho S129) | Anti-phospho-α-Synuclein (Ser129) Antibody | MABN826 | mouse human | EM;ICC;IF;IHC;WB |
Alpha-synuclein filament-conformation-specific | Anti-Aggregated a-Synuclein Antibody | MABN389 | human | ELISA;IF;WB |
DJ1 (PARK7) | Anti-DJ-1 antibody | SAB4500248 | mouse human | ELISA;IF;IHC;WB |
LRRK2 | Anti-LRRK2 Antibody | ABN187 | human mouse | IF;IHC;IP;WB |
LRRK2 (phospho S935) | Anti-Phospho-LRRK2-S935 antibody | SAB5701917 | human mouse rat | WB |
PSD95 | Anti-PSD95 Antibody | P246 | rat | IF; IP;WB |
MABN1190 | rat human | IHC;WB |
亨廷顿舞蹈症
经功能失调和退化。(Huntington’s disease, HD)是由于亨廷顿基因上多核苷酸重复序列的错误表达，影响了不同的分子通路，最终导致神经功能失调和退化。
靶点 | 名称 | 货号 | Species | Application |
HTT | Anti-HTT antibody | HPA026114 | human | ICC, IHC |
HSP70 | Anti-Heat Shock Protein 70 (HSP70) antibody | SAB4200714 | plant bovine rabbit chicken human fish insect monkey dog rat sea urchin mouse | ELISA;IF;IHC;WB |
BDNF | Anti-BDNF antibody | SAB2108004 | horse rat rabbit dog mouse human pig | WB;IHC |
Rab4 | Anti-Rab4 antibody | R5780 | human rat mouse | IF;WB |
NFL | Anti-Neurofilament L Antibody | AB9568 | rat pig human bovine feline canine mouse | ICC;IHC;WB |
神经干细胞标志物
胚胎干细胞或iPS可诱导发育成神经干细胞，它们表达重要的标志物，如巢蛋白，SOX2等，而神经干细胞可进一步分化成神经胶质祖细胞和神经前体细胞。
靶点 | 名称 | 货号 | Species | Application |
Nestin | Anti-Nestin Antibody | MAB353 | mouse rat | ICC;IHC;WB |
MAB5326 | human | ICC;IHC;WB | ||
Sox2 | Anti-Sox2 Antibody | AB5603 | human mouse | ICC;IF;IHC;WB |
Sox1 | Anti-Sox1 Antibody | AB15766 | rat mouse rodent human | IHC;WB |
NSE | Anti-NSE antibody | SAB4500768 | mouse human rat | ELISA;IF;IHC;WB |
PAX6 | Anti-PAX6 Antibody | AB2237 | mouse rat chicken | ICC;WB |
神经元
成熟神经元（mature neurons）
靶点 | 名称 | 货号 | Species | Application |
NeuN | Anti-NeuN Antibody | MAB377 | avian pig chicken human rat salamander ferret mouse | FACS;IF;IHC;WB |
MAP2 | Anti-Microtubule-Associated Protein 2 (MAP2) Antibody | AB5622 | rat mouse human | ELISA;ICC;IHC;WB |
尾-Tubulin III | Anti-尾-Tubulin III Antibody | T 2200 | rat, human, mouse | IF, IP, WB |
Neurofilament 200 | Anti-Neurofilament 200 kDa Antibody | MAB5266 | human mouse monkey rat pig | IHC;WB |
Synaptophysin | Anti-Synaptophysin Antibody | MABN1193 | mouse rat human | IHC;WB |
PSD95 | Anti-PSD95 antibody | P246 | rat | IF;IP,WB |
MABN1190 | rat human | IHC;WB |
胆碱能神经元（Cholinergic neurons）
胆碱能神经能合成乙酰胆碱,兴奋时能从末梢释放乙酰胆碱。皮层和其他脑区的胆碱能神经元可参与睡眠、运动机能、攻击行为，特别是学习和记忆等高级功能的调节。
靶点 | 名称 | 货号 | Species | Application |
ChAT | Anti-Choline Acetyltransferase Antibody | AB144P | human opossum guinea pig rat mouse zebrafish. avian monkey chicken | IHC(P);ICC;IHC;WB |
VAChT | Anti-Vesicular Acetylcholine Transporter (VAChT) Antibody | ABN100 | mouse rat | ELISA;IHC |
Acetylcholinesterase | Anti-Acetylcholinesterase Antibody | MAB303 | canine bovine human chicken guinea pig monkey | ELISA;IHC;IP |
多巴胺能神经元（Dopaminergic neurons）
多巴胺能神经元会产生多巴胺，多巴胺是一种能够影响情绪和奖励等神经功能的神经递质。多巴胺能神经元逐渐丧失会引发许多与帕金森症有关的运动症状。
靶点 | 名称 | 货号 | Species | Application |
Tyrosine hydroxylase | Anti-Tyrosine Hydroxylase Antibody | AB152 | human mollusk feline ferret Aplysia (marine mollusc) rat squid Drosophila mouse | ELISA;IF;IHC;IHC(P);IP;WB |
Dopamine transporter | Anti-Dopamine Transporter Antibody | MAB369 | rat human mouse monkey | ICC;IHC;WB |
FOXA2 | Anti-HNF3 β/FOXA2 Antibody | 07-633 | mouse human rat | IHC;WB |
GIRK2 | Anti-Potassium Channel KIR3.2 (GIRK2) antibody | P8122 | mouse rat | WB |
ALDH1A1 | Anti-ALDH1A1 antibody | HPA002123 | human | ICC, IHC, WB |
谷氨酸能神经元（glutamatergic neurons）
谷氨酸能神经元是一类能释放兴奋性递质谷氨酸（Glutamate）到突触间隙，产生兴奋性突触后电流的神经元。作为中枢神经系统中最重要的兴奋性神经元，调节着释放进入突触间隙谷氨酸递质的量，参与了几乎所有脑功能活动。
靶点 | 名称 | 货号 | Species | Application |
VGLUT1 | Anti-Vesicular Glutamate Transporter 1 Antibody | AB5905 | rat | IHC |
VGLUT2 | Anti-VGluT2 Antibody | AB2251-I | rat mouse | IHC;WB |
NMDAR2B | Anti-NMDAR2B Antibody | AB1557P | mouse rat human | IHC;IP;WB |
Glutaminase | Anti-GLS antibody | HPA036223 | human | WB, IHC, ICC |
Glutamine synthetase | Anti-Glutamine Synthetase Antibody | MABN1182 | human rat | IHC;WB |
GABA神经元（GABA neurons）
GABA是γ-氨基丁酸的简称，是中枢神经系统重要的神经递质。GABA能神经元是指主要以GABA为递质的那部分神经细胞。GABA是抑制性神经递质，对学习和记忆力以及睡眠有影响。
靶点 | 名称 | 货号 | Species | Application |
GABA transporter 1 | Anti-GABA Transporter-1 Antibody | AB1570 | monkey feline rat human mouse rabbit | IHC |
GABAB receptors 1 and 2 | Anti-Glutamate Receptor Delta 1/2 Antibody | AB2285 | rat mouse primate human | WB |
GAD65 | Anti-GAD2/GAD65 antibody | SAB2500444 | human mouse chimpanzee rat canine | ELISA;WB |
GAD67 | ANTI-GAD67 ANTIBODY | MAB5406 | All | #N/A |
5-羟色胺能神经元
（5-hydroxytryptaminergic neurons）
5-羟色胺又名血清素，在大脑皮层质及神经突触内含量很高，它也是一种抑制性神经递质。在外周组织，5-羟色胺是一种强血管收缩剂和平滑肌收缩刺激剂。在体内，5-羟色胺可以经单胺氧化酶催化成5-羟色醛以及5-羟吲哚乙酸而随尿液排出体外。
靶点 | 名称 | 货号 | Species | Application |
TPH | Anti-TPH Antibody | AB1541 | human rat | IHC;WB |
T0678 | human monkey rabbit rat | IHC;ELISA;ARR;WB | ||
TPH1 | Anti-TPH-1 Antibody | ZRB1305 | mouse human | IHC(P), ICC, WB |
TPH2 | Monoclonal Anti-TPH2 antibody produced in mouse | AMAB91108 | mouse rat human | IHC |
Serotonin transporter | Anti-Serotonin Transporter Antibody | AB9726 | mouse rat | IHC;IP;WB |
星形胶质细胞
星形胶质细胞能支持神经网络，可表达神经递质受体，在神经元交流中发挥重要重要，一般是由神经胶质祖细胞分化而来，表达标志物GFAP，S100B等。
靶点 | 名称 | 货号 | Species | Application |
GFAP | Anti-Glial Fibrillary Acidic Protein antibody(GFAP) | G3893 | rat human pig | WB;ICC;IHC;IF;ARR |
MAB360 | rat human mouse rabbit chicken pig bovine | ICC;IHC;WB | ||
S100B | Monoclonal Anti-S100B antibody | AMAb91038 | human rat mouse | IHC, WB |
ALDH1L1 | Anti-Aldh1L1 Antibody | MABN495 | human rat mouse | IF;IHC;WB |
AQP4 | Anti-AQP4 antibody | HPA014784 | human mouse | ICC, IHC, WB |
小胶质细胞
小胶质细胞是遍布大脑和脊髓的一种神经胶质细胞, 作为大脑中的巨噬细胞，在中枢神经系统（CNS）中作为免疫防御的第一线发挥着重要作用。
靶点 | 名称 | 货号 | Species | Application |
Iba1 | Anti-Iba1/AIF1 Antibody | MABN92 | rat mouse human | IHC;WB |
TMEM119 | Anti-TMEM119 antibody | HPA051870 | human | IHC |
CD45 | Anti-CD45 antibody | SAB4502541 | rat mouse human | ELISA;IF;IHC |
CD11b | Anti-Integrin 伪M [CD11b] Antibody | CBL1512Z | rat | FC;IHC;IP |
CX3CR1 | Anti-CX3CR1 antibody | SAB3500204 | mouse human rat | FACS;IF;IHC;ELISA;WB |
F4/80 | Anti-F4/80 Antibody | ZRB1277 | human mouse | FC, ABA, IHC(P), WB |
CD68 | Anti-CD68 antibody | HPA048982 | human | IHC, WB |
CD40 | Anti-CD40 antibody | SAB4503674 | mouse human | ELISA;IHC;WB |
少突胶质细胞
少突胶质细胞负责髓鞘的形成，髓鞘隔离中枢神经系统中的轴突。其作用与施旺细胞在周围神经系统中的功能类似，可分为少突胶质细胞前体细胞和成熟少突胶质细胞。
靶点 | 名称 | 货号 | Species | Application |
NG2 | Anti-NG2 Chondroitin Sulfate Proteoglycan Antibody | AB5320 | rat mouse monkey human | IELISA;ICC;IHC;IP;WB |
Olig 2 | Anti-Olig2 Antibody | AB9610 | mouse human rat | ICC;IHC;IHC(P);IP;WB |
Olig 2 | Anti-Olig2 Antibody | MABN50 | mouse | ICC;IHC;IP;WB |
MBP | Anti-Myelin Basic Protein Antibody | M3821 | rat, human, mouse | FACS, IHC, WB |
MOG | Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody | MAB5680 | rat mouse | FC;ICC;IHC;WB |
SOX10 | Anti-SOX10 antibody | HPA068898 | human | ICC, IHC |
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