【 Peptides&elephants/JPT 】Polyomaviridae(多瘤病毒)相关多肽库

【 Peptides&elephants/JPT 】Polyomaviridae(多瘤病毒)相关多肽库

多瘤病毒科(Polyomaviridae)是一种双链DNA病毒,基因组长约5000bp,为双股环状DNA。多瘤病毒可改变培养的细胞,且对实验性啮齿动物有致瘤性。

感染人的多瘤病毒主要有两种:多瘤病毒BK和多瘤病毒JC。JCV是进行性多灶性脑白质病(PML)的致病原,人类多瘤病毒为中枢神经系统的一种进行性退化性疾病,发生于免疫功能减低者,其DNA使新生仓鼠胶质细胞的原代培养细胞发生转化。BKV与某些泌尿系统疾病有关,可诱发新生的仓鼠和小鼠产生肿瘤,在体外能使仓鼠、大鼠、小鼠家兔和非洲绿猴细胞发生转化,BKV的DNA也能转化大鼠和仓鼠细胞。

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