【JPT/Peptides&elephants】革兰氏阴性菌相关多肽库

【JPT/Peptides&elephants】革兰氏阴性菌相关多肽库

革兰氏阴性菌


●Bordetella pertussis(百日咳博德特氏杆菌)

百日咳博德特氏杆菌(Bordetella pertussis)是一种革兰氏阴性、好氧性、博德氏菌属的球杆菌。百日咳杆菌在特定条件下可以产生鞭毛,具有能动性。其致病物质包括了荚膜、菌毛、内毒素和多种生物活性物质。菌毛有利于菌体黏附,荚膜有抗吞噬作用。毒素主要包括五种:百日咳毒素(pertussis toxin)、腺苷酸环化酶毒素(adenylate cyclase toxin)、气管细胞毒素(tracheal cytotoxin)、皮肤坏死毒素以及丝状血凝素(filamentous hemagglutinin)。


●Tularemia(土拉杆菌病)

土拉杆菌是一种微小(0.3~0.7×0.2μm)、无活动力的革兰氏阴性球杆菌,在培养基上可具多形性,在组织内可形成荚膜。

该菌有三种抗原多糖抗原、细胞壁及胞膜抗原(免疫性和内毒素作用)、蛋白抗原(可产生迟发型变态反应)。土拉杆菌在自然界生存力较强,但对理化因素抵抗力不强,加热55~60℃、10分钟即死亡,普通消毒剂可灭活,但对低温、干燥的抵抗力较强。

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