【Merck】肿瘤研究抗体

提供多种肿瘤研究抗体，覆盖自噬、凋亡、增殖、信号转导等多个研究方向。来自人类蛋白质组学计划的HPA“金标抗体”，每个抗体可以提供700张细胞和组织中的验证图片。

LC3是自噬研究的热门靶标。可应用于肿瘤，免疫，神经，发育等多个研究方向。

文献引用率高：超过1520篇引用文献，LC3B抗体文献引用率领先列三甲。（数据来自CiteAb）

多种实验验证：IF，WB等实验验证。

抗体特异性高

提供100ul和200ul两个规格

参考文献：

Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome.

In Nature Communications on 2 November 2017 by Li, C., Brazill, J. M., et al..

A novel Fer/FerT targeting compound selectively evokes metabolic stress and necrotic death in malignant cells.

In Nature Communications on 16 October 2017 by Elkis, Y., Cohen, M., et al..

Quantifying autophagy using novel LC3B and p62 TR-FRET assays.

In PLoS ONE on 20 March 2018 by Bresciani, A., Spiezia, M. C., et al..

Discovery of pan autophagy inhibitors through a high-throughput screen highlights macroautophagy as an evolutionarily conserved process across 3 eukaryotic kingdoms.

In Autophagy on 2 September 2017 by Mishra, P., Dauphinee, A. N., et al..

Impaired spliceosomal UsnRNP assembly leads to Sm mRNA down-regulation and Sm protein degradation.

In The Journal of Cell Biology on 7 August 2017 by Prusty, A. B., Meduri, R., et al..

P62蛋白与细胞自噬和凋亡密切相关，是检测细胞自噬的标志物。应用于肿瘤，神经，免疫，发育，代谢等多个研究领域。

多实验验证：WB, IF, IP

性价比高：200ul包装

上百篇文献引用率。

参考文献：

TLR4-mediated autophagic impairment contributes to neuropathic pain in chronic constriction injury mice.

In Molecular Brain on 27 February 2018 by Piao, Y., Gwon, D. H., et al..

Standard Immunohistochemical Assays to Assess Autophagy in Mammalian Tissue.

In Cells on 30 June 2017 by Martinet, W., Roth, L., et al..

Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling.

In Nature Communications on 13 June 2017 by Qi, N., Shi, Y., et al..

SPHK1 (sphingosine kinase 1) induces epithelial-mesenchymal transition by promoting the autophagy-linked lysosomal degradation of CDH1/E-cadherin in hepatoma cells.

In Autophagy on 4 May 2017 by Liu, H., Ma, Y., et al..

Infectious Bursal Disease Virus Subverts Autophagic Vacuoles To Promote Viral Maturation and Release.

In Journal of Virology on 1 March 2017 by Wang, Y., Duan, Y., et al..

抗磷脂酶A2受体的抗体。特发性膜性肾病的标志物，参与细胞衰老和炎症反应中。

多实验验证:提供在正常组织，疾病组织和细胞中的多组验证结果。

高稀释倍数：IHC: 1:1000-1:2500; WB: 0.4ug/ml

参考文献：

PLA2R1 mediates tumor suppression by activating JAK2.

In Cancer Research on 15 October 2013 by Vindrieux, D., Augert, A., et al..

PLA2R autoantibodies and PLA2R glomerular deposits in membranous nephropathy.

In The New England Journal of Medicine on 17 February 2011 by Debiec, H. & Ronco, P..

Ultrasensitive Quantitation of Anti-Phospholipase A2 Receptor Antibody as A Diagnostic and Prognostic Indicator of Idiopathic Membranous Nephropathy.

In Scientific Reports on 21 September 2017 by Zhang, Q., Huang, B., et al..

Response to immunosuppressive therapy in PLA2R- associated and non-PLA2R associated idiopathic membranous nephropathy: a retrospective, multicenter cohort study.

In BMC Nephrology on 10 July 2017 by Wang, J., Xie, Q., et al..

Membranous Nephropathy Associated With Immunological Disorder-Related Liver Disease: A Retrospective Study of 10 Cases.

In Medicine on 1 July 2015 by Dauvergne, M., Moktefi, A., et al..

VEGF是血管内皮生长因子，与细胞迁移，血管生成和肿瘤研究密切相关。

多实验验证： WB，ELISA, IHC, neutralization

多种属验证：human, primate

参考文献：

Disruption of astrocyte-vascular coupling and the blood-brain barrier by invading glioma cells.

In Nature Communications on 19 June 2014 by Watkins, S., Robel, S., et al..

VEGF receptor signaling - in control of vascular function.

In Nature Reviews. Molecular Cell Biology on 1 May 2006 by Olsson, A. K., Dimberg, A., et al..

The biology of VEGF and its receptors.

In Nature Medicine on 1 June 2003 by Ferrara, N., Gerber, H. P., et al..

VEGF162, a new heparin-binding vascular endothelial growth factor splice form that is expressed in transformed human cells.

In The Journal of Biological Chemistry on 9 May 2003 by Lange, T.,Guttmann-Raviv, N., et al..

Identification of a peptide blocking vascular endothelial growth factor (VEGF)-mediated angiogenesis.

In The EMBO Journal on 3 April 2000 by Binétruy-Tournaire, R., Demangel, C., et al..