【Merck】表观遗传学相关抗体

来自Upstate子品牌。该品牌在表观遗产学研究领域有三十多年的历史，开发出第一个商业化的ChIP和RIP试剂盒，提供全面的ChIP/RIP级验证抗体，表观产品文献应用超过50万篇，深受广大科研者的信赖和好评。

乙酰化组蛋白H3抗体。组蛋白乙酰化与激活基因表达相关。在肿瘤研究中应用广泛。很多植物研究也涉及到该靶点。

文献引用率高：超过2250篇引用文献。乙酰化组蛋白H3抗

体文献引用率名列首位。（数据来自CiteAb）

多实验验证：WB, ICC, ChIP-seq, ChIP

抗体特异性高

有文献报道可用于玉米等植物的WB、ChIP实验

参考文献：

Nuclear quiescence and histone hyper-acetylation jointly improve protamine-mediated nuclear remodeling in sheep fibroblasts.

In PLoS ONE on 16 March 2018 by Palazzese, L., Czernik, M., et al..

Muscle-Specific Histone H3K36 Dimethyltransferase SET-18 Shortens  Lifespan of Caenorhabditis elegans by Repressing daf-16a Expression.

In Cell Reports on 6 March 2018 by Su, L., Li, H., et al..

HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130.

In Nature Communications on 22 February 2018 by Göder, A., Emmerich,C., et al..

The Distinct Roles of Class I and II RPD3-Like Histone Deacetylases in Salinity Stress Response.

In Plant Physiology on 1 December 2017 by Ueda, M., Matsui, A., et al..

NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection.

In Nature Communications on 16 October 2017 by Wang, J., He, N., et al..

组蛋白H3 27位赖氨酸甲基化通常与基因沉默相关。可应用与遗传发育，干细胞，免疫，肿瘤等研究方面。

文献引用率高：trimethyl-Histone H3抗体文献引用率超过

2290篇，排名首位。（数据来自CiteAb网站）

多实验验证：ICC, IP, Mplex, WB, IHC，ChIP, ChIP-seq

高特异性抗体：经过protein A纯化

性价比高：200ug包装

提供多种荧光直标的抗体：-AF488, -AF647, -AF555

参考文献：

VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma.

In Cancer Discovery on 1 November 2017 by Yao, X., Tan, J., et al..

EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop.

In Nature Communications on 12 October 2017 by Béguelin, W., Rivas, M. A., et al..

Disruption of an RNA-binding hinge region abolishes LHP1-mediated epigenetic repression. In Genes and Development on 1 November 2017 by Berry, S., Rosa,S., et al..

CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression. (View PDF)

In Nature Communications on 25 August 2017 by Liu, Y., Lai, S., et al..

Cytokinin Signaling Activates WUSCHEL Expression during Axillary Meristem Initiation.

In The Plant Cell on 1 June 2017 by Wang, J., Tian, C., et al..

文献引用率高：phospho-Histone H2A.X抗体文献引用率超过3250篇，排名首位。（数据来自CiteAb网站）

多实验验证：ICC, IF, WB, ChIP

多种属验证：脊椎动物

高特异性：单克隆抗体，protein G纯化

高稀释倍数：WB实验最高稀释倍数达1：20000

高性价比：200ug包装。

提供多种荧光直标的抗体：-AF488, -AF555

参考文献

Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations.

In Nature Communications on 7 February 2018 by Cohen, S., Puget, N., et al..

BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage.

In Nature Communications on 7 February 2018 by Biswas, K., Philip, S., et al..

ATR Is a Therapeutic Target in Synovial Sarcoma.

In Cancer Research on 15 December 2017 by Jones, S. E., Fleuren, E. D. G., et al..

Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus.

In Journal of Virology on 15 November 2017 by Hollingworth, R., Horniblow, R.D., et al..

Relief of endoplasmic reticulum stress enhances DNA damage repair and improves development of pre-implantation embryos.

In PLoS ONE on 4 November 2017 by Dicks, N., Bohrer, R. C., et al..

TRIMETHYL-HIST H3 (LYS4)与基因转录激活相关，与肿瘤的发生、增殖和凋亡等研究相关。

文献引用率高：抗体文献引用超过1070篇，位居首位（数据来自CiteAb网站。）

多实验验证：DB, WB, ChIP-seq, ChIP

多种属验证：Human，Vertebrates

高稀释倍数：WB稀释倍数高达1：10000

提供荧光直标的抗体：-AF488，-AF555，-AF647

参考文献：

MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state.

In Nature Communications on 9 March 2018 by Poli, V., Fagnocchi, L., et al..

Induction of epigenetic variation in Arabidopsis by over-expression of DNA METHYLTRANSFERASE1 (MET1).

In PLoS ONE on 22 February 2018 by Brocklehurst, S., Watson, M., et al..

Chromatin organization changes during the establishment and maintenance of the postmitotic state.

In Epigenetics &; Chromatin on 10 November 2017 by Ma, Y. & Buttitta, L..

Structural and Functional Basis for an EBNA1 Hexameric Ring in Epstein-Barr Virus Episome Maintenance.

In Journal of Virology on 1 October 2017 by Deakyne, J. S., Malecka, K. A., et al..

Excess Translation of Epigenetic Regulators Contributes to Fragile X Syndrome and Is Alleviated by Brd4 Inhibition.

In Cell on 7 September 2017 by Korb, E., Herre, M., et al..