【JPT/Peptides&elephants】双链DNA逆转录病毒相关多肽库( dsDNA-RT viruses )

【JPT/Peptides&elephants】双链DNA逆转录病毒相关多肽库( dsDNA-RT viruses )

双链DNA逆转录病毒( dsDNA-RT viruses )

Hepatitis B virus(乙型肝炎病毒)

乙型肝炎病毒(Hepatitis B virus,HBV)是一种DNA病毒,属嗜肝DNA病毒科,是直径42nm的球形颗粒。HBV的基因组约含3200个碱基对。长链的长度固定,有一缺口处为DAN聚合酶;短链的长度不定。HBV的长链有4个开放性读框(ORF),即S区、C区、P区和X区。S区包括前S1前S2和S区基因,编码前S1、前S2和S三种外壳蛋白;C区以包括前C区,C区基因编码HBcAg蛋白,前C区编码一个信号肽,在组装和分泌病毒颗粒以及在HBeAg的分泌中起重要作用;P基因编码DNA聚合酶;X基因的产物是X蛋白,其功能尚不清楚。HBV的短链不含开放读框,因此不能编码蛋白。

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