avidity 品牌介绍
品牌简介
Avidity，LLC成立于1996年，基于生物素对抗生物素蛋白或链霉抗生物素蛋白的非凡亲和力开发肽标签和分子生物学产品。在Affymax担任研究员期间，Millard参与了AviTag技术的发现，发现了其商业潜力，并获得了Affymax的专有权。他创建了Avidity作为试剂公司，将AviTag技术的使用权转让给其他公司，并销售与该技术一起使用的产品。 Avidity, LLC was founded in 1996 by Millard Cull, Larry Lansing, Dr. Ron Gill, and Dr. Mark Seville to develop peptide tags and molecular biology products based upon the extraordinary affinity of biotin for avidin or streptavidin. While working at Affymax as a researcher, Millard was involved in the discovery of the AviTag technology, saw its commercial potential, and obtained the exclusive rights from Affymax. He started Avidity as a reagent company that sublicenses the right to use the AviTag technology to other companies and sells products for use with the technology. main products BirA Enzyme and buffers for in vitro biotinylation Cell lines for in vivo biotinylation Avidity ATUM AviTag™ vectors Purification and Identification of Avitag'd proteins Purified Proteins and support chemicals https://www.avidity.com
AviTag是一种获得zhuan利的生物素标记技术，由Peter Schatz博士在Affymax中发现，其定向进化方法称为“肽质上的肽”。定向进化方法鉴定了许多可以被大肠杆菌的BirA酶生物素化的肽序列，这些序列中的被称为AviTag。大肠杆菌酶BirA将15个氨基酸的AviTag生物素化为其天然底物生物素羧基载体蛋白（BCCP）的两倍。
使用AviTag技术的蛋白质的酶促生物素化优于蛋白质的化学生物素化，因为BirA酶温和且高度特异性地标记AviTag的赖氨酸残基。在AviTag之前，小的生物素接受结构域由75个氨基酸组成。
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